If you are traveling Wednesday or Wednesday night between Asheville and Boston, you have a chance of major travel disruptions. At best, it will be windy and rainy. At worst, there will be heavy snow with high winds. Here is a preliminary forecast snow accumulations from 4am until 4pm (EST) Wednesday.
My (free) airline survival guide tells you, step by step, how to do it. I suspect the airlines may issue waivers (some call them "exemptions" now) as early as Monday.